Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …

Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the
development of autoimmune diseases. However, Treg cells are abundant in tumors and …

The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from
poorly understood immunological dysfunction. We hypothesized that perturbations in …

Background & Aims The landscape and function of the immune infiltrate of intrahepatic
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly …

Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …

A still unanswered question is what drives the small fraction of activated germinal center
(GC) B cells to become long-lived quiescent memory B cells. We found here that a small …

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune
responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression …

Mutations of the transcription factor FoxP3 in patients with" IPEX"(immune dysregulation,
polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg) …

The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

Murine myeloid cells are developed from hemopoietic stem/progenitor cells. Different types
of progenitor cells have variable differentiation potentials. Among the ten main types of cells …