Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Drugs whose targets have genetic evidence to support efficacy and safety are more likely to
be approved after clinical development. In this paper, we provide an overview of how natural …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

The human proteome is a major source of therapeutic targets. Recent genetic association
analyses of the plasma proteome enable systematic evaluation of the causal consequences …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms
are incompletely understood. The discovery of disease-associated proteins with causal …

OBJECTIVE To investigate the causal role of choline metabolites mediating sodium–glucose
cotransporter 2 (SGLT2) inhibition in coronary artery disease (CAD) and type 2 diabetes …