Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

Covering: 2017–2019 Guanidine natural products isolated from microorganisms, marine
invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …

Covering 2011 to 2022Low titers of natural products in laboratory culture or fermentation
conditions have been one of the challenging issues in natural products research. Many …

Nucleoside antibiotics are a diverse class of natural products with promising biomedical
activities. These compounds contain a saccharide core and a nucleobase. Despite the large …

C‐Nucleosides are characterized by a C− C rather than a C− N linkage between the
heterocyclic base and the ribofuranose ring. While the biosynthesis of pseudouridine‐C …

Pseudouridine-incorporated mRNA vaccines can enhance protein expression and reduce
immunogenicity, leading to a high demand for pseudouridine to be used in mRNA drug …

Microbes are talented chemists with the ability to generate tremendously complex and
diverse natural products which harbor potent biological activities. Natural products are …