Since its discovery twenty-five years ago, the fat-derived hormone leptin has provided a
revolutionary framework for studying the physiological role of adipose tissue as an …

Adipose tissue dysfunction plays an important role in metabolic diseases associated with
chronic inflammation, insulin resistance and lipid ectopic deposition in obese patients. In …

Objective Mitochondrial dysfunction plays a dominant role in the pathogenesis of alcoholic
liver disease (ALD); however, the underlying mechanisms remain to be fully understood. We …

Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle
metabolism remain poorly defined. The primary aim of this study was to determine whether …

Ethnopharmacological relevance Prunella vulgaris L.(PVL) is a perennial herb belonging to
the Labiate family, first recorded in the “Shen Nong's Classic of the Materia Medica”. PVL …

Background Short-chain chlorinated paraffins (SCCPs) used in various industrial
applications have been listed as new POPs. Previous studies based on high-dose …

Lipin‐1 is a Mg2+‐dependent phosphatidic acid phosphohydrolase involved in the
generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol …

Background: Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …

Alcohol-related liver disease (ALD) is a major cause of morbidity and mortality worldwide. It
encompasses conditions such as fatty liver, alcoholic hepatitis, chronic hepatitis with liver …

Large yellow croaker roe phospholipids (LYCRPLs) could regulate the accumulation of
triglycerides and blood lipid levels. However, there exists little research on the mechanism of …