Understanding the interaction of polyelectrolyte architectures with proteins and biosystems

K Achazi, R Haag, M Ballauff… - Angewandte Chemie …, 2021 - Wiley Online Library
The counterions neutralizing the charges on polyelectrolytes such as DNA or heparin may
dissociate in water and greatly influence the interaction of such polyelectrolytes with …

Respiratory viruses interacting with cells: The importance of electrostatics

D Lauster, K Osterrieder, R Haag, M Ballauff… - Frontiers in …, 2023 - frontiersin.org
The COVID-19 pandemic has rekindled interest in the molecular mechanisms involved in
the early steps of infection of cells by viruses. Compared to SARS-CoV-1 which only caused …

Differences of the tumour cell glycocalyx affect binding of capsaicin-loaded chitosan nanocapsules

L von Palubitzki, Y Wang, S Hoffmann, S Vidal-y-Sy… - Scientific Reports, 2020 - nature.com
The glycocalyx regulates the interaction of mammalian cells with extracellular molecules,
such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer …

Thermodynamic analysis of the interaction of heparin with lysozyme

JJ Walkowiak, M Ballauff, R Zimmermann… - …, 2020 - ACS Publications
Glycosaminoglycan (GAG)–protein binding governs critically important signaling events in
living matter. Aiming at a quantitative analysis of the involved processes, we herein present …

Interaction of the heparin-binding consensus sequence of β-amyloid peptides with heparin and heparin-derived oligosaccharides

K Nguyen, DL Rabenstein - The journal of physical chemistry B, 2016 - ACS Publications
Alzheimer's disease (AD) is characterized by the presence of amyloid plaques in the AD
brain. Comprised primarily of the 40-and 42-residue β-amyloid (Aβ) peptides, there is …

Conformational Modulation of Iduronic Acid‐Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of …

AK Gorle, T Haselhorst, SJ Katner… - Angewandte Chemie …, 2021 - Wiley Online Library
Abstract 1H NMR spectroscopic studies on the 1: 1 adduct of the pentasaccharide
Fondaparinux (FPX) and the substitution‐inert polynuclear platinum complex TriplatinNC …

[HTML][HTML] Driving Forces in the Formation of Biocondensates of Highly Charged Proteins: A Thermodynamic Analysis of the Binary Complex Formation

M Ballauff - Biomolecules, 2024 - mdpi.com
A thermodynamic analysis of the binary complex formation of the highly positively charged
linker histone H1 and the highly negatively charged chaperone prothymosin α (ProTα) is …

Interaction of heparin with proteins: hydration effects

W Malicka, R Haag, M Ballauff - The Journal of Physical Chemistry …, 2022 - ACS Publications
We present a thermodynamic investigation of the interaction of heparin with lysozyme in the
presence of potassium glutamate (KGlu). The binding constant K b is measured by …

Molecular dynamics simulations illuminate the role of counterion condensation in the electrophoretic transport of homogalacturonans

AH Irani, JL Owen, D Mercadante… - …, 2017 - ACS Publications
Homogalacturonans (HGs) are polysaccharide copolymers of galacturonic acid and its
methylesterified counterpart. The inter-and intramolecular distributions of the methylesterifed …

Exothermic–Endothermic Transition in the Titration of Poly (allylamine chloride) with Sodium Hexametaphoshate Associated with a Change in the Proton Release …

C Maechling, V Ball - The Journal of Physical Chemistry B, 2016 - ACS Publications
The formation of complexes (aggregates) between oppositely charged macromolecular
species or between macromolecular species and multivalent ions is a fascinating …