Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

The clinical presentation and the pathological processes underlying Alzheimer's disease
(AD) can be very heterogeneous in severity, location, and composition including the amount …

With the increasing availability of rich, longitudinal, real-world clinical data recorded in
electronic health records (EHRs) for millions of patients, there is a growing interest in …

In tandem with the ever‐increasing aging population in low and middle‐income countries,
the burden of dementia is rising on the African continent. Dementia prevalence varies from …

Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Background Multiple pathophysiological processes have been described in Alzheimer's
disease (AD). Their inter-individual variations, complex interrelations, and relevance for …

Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …

Large, open datasets have emerged as important resources in the field of human
connectomics. In this review, the evolution of data sharing involving magnetic resonance …