Onchocerciasis-associated epilepsy: an update and future perspectives

A Hadermann, LJ Amaral, G Van Cutsem… - Trends in …, 2023 - cell.com
Onchocerciasis-associated epilepsy (OAE) is an important neglected public health problem
in areas with high ongoing onchocerciasis transmission. The risk that children in such areas …

[HTML][HTML] Helminth extracellular vesicles: Interactions with the host immune system

C Drurey, RM Maizels - Molecular Immunology, 2021 - Elsevier
As long-lived parasites, helminths depend upon immunomodulation of their hosts for
survival. The release of excretory-secretory (ES) products, including proteins, lipids and …

Onchocerca volvulus and epilepsy: A comprehensive review using the Bradford Hill criteria for causation

R Colebunders, AK Njamnshi, S Menon… - PLoS neglected …, 2021 - journals.plos.org
Background The possibility that onchocerciasis may cause epilepsy has been suggested for
a long time, but thus far, an etiological link has not been universally accepted. The objective …

Invited Review: The role of prion‐like mechanisms in neurodegenerative diseases

Z Jaunmuktane, S Brandner - Neuropathology and Applied …, 2020 - Wiley Online Library
The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …

Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome

AWD Edridge, G Abd-Elfarag, M Deijs… - Brain …, 2023 - academic.oup.com
Nodding syndrome is a neglected, disabling and potentially fatal epileptic disorder of
unknown aetiology affecting thousands of individuals mostly confined to Eastern sub …

Chronic effects of inflammation on tauopathies

C Langworth-Green, S Patel, Z Jaunmuktane… - The Lancet …, 2023 - thelancet.com
Tauopathies are a heterogeneous group of neurodegenerative disorders that are
characterised by the aggregation of the microtubule-associated protein tau into filamentous …

Infection elicited autoimmunity and myalgic encephalomyelitis/chronic fatigue syndrome: an explanatory model

J Blomberg, CG Gottfries, A Elfaitouri… - Frontiers in …, 2018 - frontiersin.org
Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a
common, debilitating, disease of unknown origin. Although a subject of controversy and a …

Onchocerciasis (river blindness)–more than a century of research and control

NW Brattig, RA Cheke, R Garms - Acta Tropica, 2021 - Elsevier
This review summarises more than a century of research on onchocerciasis, also known as
river blindness, and its control. River blindness is an infection caused by the tissue filaria …

The temporal relationship between onchocerciasis and epilepsy: a population-based cohort study

CB Chesnais, HC Nana-Djeunga… - The Lancet Infectious …, 2018 - thelancet.com
Background Many studies have suggested that onchocerciasis might be associated with
epilepsy. Therefore, we did a cohort study to assess the incidence of epilepsy relative to …

A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current …

P Jittamala, W Monteiro, MR Smit… - PLoS neglected …, 2021 - journals.plos.org
Background Oral ivermectin is a safe broad spectrum anthelminthic used for treating several
neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children …