The molecular mechanisms of intestinal inflammation and fibrosis in Crohn's disease

Y Hayashi, H Nakase - Frontiers in physiology, 2022 - frontiersin.org
Crohn's disease (CD) is an inflammatory bowel disease (IBD) with repeated remissions and
relapses. As the disease progresses, fibrosis and narrowing of the intestine occur, leading to …

Inflammatory bowel disease and cardiovascular diseases: a concise review

H Wu, T Hu, H Hao, MA Hill, C Xu… - European Heart Journal …, 2022 - academic.oup.com
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality
despite aggressive treatment of traditional risk factors. Chronic inflammation plays an …

Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis

T Burstyn-Cohen, ED Lew, PG Través, PG Burrola… - Neuron, 2012 - cell.com
Although TAM receptor tyrosine kinases play key roles in immune regulation, cancer
metastasis, and viral infection, the relative importance of the two TAM ligands—Gas6 and …

Immunothrombosis: molecular aspects and new therapeutic perspectives

M Marcos-Jubilar, R Lecumberri… - Journal of Clinical …, 2023 - mdpi.com
Thromboinflammation or immunothrombosis is a concept that explains the existing link
between coagulation and inflammatory response present in many situations, such as sepsis …

[HTML][HTML] Venous thromboembolism in inflammatory bowel disease

K Cheng, AS Faye - World journal of gastroenterology, 2020 - ncbi.nlm.nih.gov
Patients with inflammatory bowel disease (IBD) are at an increased risk for venous
thromboembolism (VTE). VTE events carry significant morbidity and mortality, and have …

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin (ogen)

DB Kell, E Pretorius - Integrative Biology, 2015 - academic.oup.com
Although the two phenomena are usually studied separately, we summarise a considerable
body of literature to the effect that a great many diseases involve (or are accompanied by) …

The journey through the pathogenesis and treatment of venous thromboembolism in inflammatory bowel diseases: a narrative review

A Boccatonda, M Balletta, S Vicari… - … in Thrombosis and …, 2023 - thieme-connect.com
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the
gastrointestinal tract including Crohn's disease and ulcerative colitis, which may result in …

Hypercoagulability and platelet abnormalities in inflammatory bowel disease

E Senchenkova, H Seifert… - Seminars in thrombosis …, 2015 - thieme-connect.com
Patients with inflammatory bowel disease (IBD) exhibit a threefold higher risk for
development of systemic thrombosis than the general population. Although the underlying …

Biological, genetic and epigenetic markers in ulcerative colitis

G Caliendo, G D'Elia, J Makker, L Passariello… - Advances in Medical …, 2023 - Elsevier
In this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers
based on current literature, specifically, the roles of potential new biomarkers, such as …

Dysregulated haemostasis in thrombo-inflammatory disease

PA Klavina, G Leon, AM Curtis, RJS Preston - Clinical Science, 2022 - portlandpress.com
Inflammatory disease is often associated with an increased incidence of venous
thromboembolism in affected patients, although in most instances, the mechanistic basis for …