Although cancer chemotherapy has historically been considered immune suppressive, it is
now accepted that certain chemotherapies can augment tumor immunity. The recent …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

The development of precision medicine for the management of metastatic breast cancer is
an appealing concept; however, major scientific and logistical challenges hinder its …

ABSTRACT Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of
the so-called “kynurenine pathway”, which converts the essential amino acid L-tryptophan …

Cancer chemotherapy drugs have long been considered immune suppressive. However,
more recent data indicate that some cytotoxic drugs effectively treat cancer in part by …

Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of
molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) …

Solid tumors are constituted of a variety of cellular components, including bona fide
malignant cells as well as endothelial, structural and immune cells. On one hand, the tumor …