Globoid cell leukodystrophy (GLD) is an autosomal recessive neurodegenerative disorder
caused by a deficiency of the lysosomal enzyme galactocerebrosidase (GALC). GALC is …

Mesenchymal stem cells (MSCs) have drawn worldwide attention of scientists and clinicians
due to their ability to differentiate into other cell lineages, secrete paracrine factors, modulate …

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and
mechanisms underlying cellular dysfunction are poorly understood. We found that toxic …

Despite the inability of CNS axons to regenerate, an increased regenerative capacity can be
elicited following conditioning lesion to the peripheral branch of dorsal root ganglia neurons …

Globoid cell leukodystrophy (GLD) is a lysosomal storage disease caused by deficient
activity of β-galactocerebrosidase (GALC). The infantile forms manifest with rapid and …

In Krabbe's disease (KD), a leukodystrophy caused by β-galactosylceramidase deficiency,
demyelination and a myelin-independent axonopathy contributes to the severe …

KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in
neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but …

Background: Stem cell-released exosomes (EXs) have shown beneficial effects on
regenerative diseases. Our previous study has revealed that EXs of endothelial progenitor …

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3, the most common
dominant spinocerebellar ataxia (SCA) worldwide, is caused by over-repetition of a CAG …

The generation of neuronal cells from stem cells obtained from adult bone marrow is of
significant clinical interest in order to design new cell therapy protocols for several …