The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …

Background. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the
frequency of expression of potential predictive biomarkers is unknown in glioma. Methods. In …

We present the case of a patient with a left frontal glioblastoma with primitive
neuroectodermal tumor features and hypermutated genotype in the setting of a POLE …

Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

Gliomas represent approximately 30% of all central nervous system tumors and 80% of
malignant brain tumors. To understand the molecular mechanisms underlying the malignant …

Purpose Germline pathogenic variants in the exonuclease domain (ED) of polymerases
POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC) …

Replication proofreading is crucial to avoid mutation accumulation in dividing cells. In
humans, proofreading and replication repair is maintained by the exonuclease domains of …

Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or
malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic …

A small fraction of cancer patients with advanced disease survive significantly longer than
patients with clinically comparable tumors. Molecular mechanisms for exceptional …