[HTML][HTML] Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential

E Gorman, J Millar, D McAuley… - Expert review of …, 2021 - Taylor & Francis
Introduction: Mesenchymal stromal (stem) cell (MSC) therapies are emerging as a promising
therapeutic intervention in patients with Acute Respiratory Distress Syndrome (ARDS) and …

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

J Liang, Y Zhang, T Xie, N Liu, H Chen, Y Geng… - Nature medicine, 2016 - nature.com
Successful recovery from lung injury requires the repair and regeneration of alveolar
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …

[HTML][HTML] Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway

X Zhang, X Wei, Y Deng, X Yuan, J Shi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal cells (MSCs) have been considered a promising alternative for
treatment of acute respiratory distress syndrome (ARDS). However, there is significant …

Mesenchymal stromal cells: an antimicrobial and host-directed therapy for complex infectious diseases

TD Shaw, AD Krasnodembskaya… - Clinical microbiology …, 2021 - Am Soc Microbiol
There is an urgent need for new antimicrobial strategies for treating complex infections and
emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells …

Concise review: the obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells

AL Strong, ME Burow, JM Gimble, BA Bunnell - Stem cells, 2015 - academic.oup.com
With the recognition of obesity as a global health crisis, researchers have devoted greater
effort to defining and understanding the pathophysiological molecular pathways regulating …

[HTML][HTML] Human adipose tissue-derived mesenchymal stem cells and their extracellular vesicles modulate lipopolysaccharide activated human microglia

M Garcia-Contreras, AS Thakor - Cell Death Discovery, 2021 - nature.com
Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), are driven by
neuroinflammation triggered by activated microglial cells; hence, the phenotypic regulation …

[HTML][HTML] Secretome from hypoxia-conditioned adipose-derived mesenchymal stem cells promotes the healing of gastric mucosal injury in a rodent model

X Xia, PWY Chiu, PK Lam, WC Chin, EKW Ng… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Studies have indicated that the definitive engraftment and transdifferentiation potential of
stem cells do not seem crucial for its property of tissue repair. Our previous study showed …

Bone marrow‐derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion‐induced lung injury

J Li, J Zhou, D Zhang, Y Song, J She… - Journal of cellular and …, 2015 - Wiley Online Library
Autophagy, a type II programmed cell death, is essential for cell survival under stress, eg
lung injury, and bone marrow‐derived mesenchymal stem cells (BM‐MSC s) have great …

[HTML][HTML] The effect of human adipose-derived stem cells on lipopolysaccharide-induced acute respiratory distress syndrome in mice

YJ Jung, YY Park, JW Huh, SB Hong - Annals of translational …, 2019 - ncbi.nlm.nih.gov
Background Acute respiratory distress syndrome (ARDS) is a type of acute respiratory failure
in critically ill patients. Recently, several treatment modalities have been proposed for …