The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Rationale: Autophagy can preserve cell viability under conditions of mild ischemic stress by
degrading damaged organelles for ATP production, but under conditions of severe …

Tumor suppressor p53 plays a central role in tumor suppression. As a transcription factor,
p53 mainly exerts its tumor suppressive function through transcriptional regulation of many …

The tumour suppressor p53 is a central player in cellular DNA damage responses. P53 is
upregulated and activated by genotoxic stress and induces a transcriptional programme with …

MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting
protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus …

The p53 transcription factor is a major tumor suppressor, whose diverse activities serve to
ensure genome stability and inhibit neoplastic processes. In recent years, it is becoming …

Recently, attention has been drawn to the role of non-coding regions of the genome in
cancer pathogenesis. MicroRNAs (miRNAs) are small non-coding RNAs with 19–25 bases …

Background: The anti-tumor effects of quercetin have been reported, but the underlying
molecular mechanisms remain to be elucidated. The aim of present study was to explore the …

Cervical cancer is the fourth most common malignancy in women worldwide and a leading
cause of cancer-related mortality in developing countries. Important etiological factors in this …