Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …

The mammalian heart contains multiple cell types that appear progressively during
embryonic development. Advance in determining cardiac lineage diversification has often …

In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell
therapy, have attracted considerable scientific and clinical attention but failed to improve …

Background: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse
roles in organ-specific lymphatic vessels. However, its physiological role in cardiac …

Background Promoting cardiac lymphangiogenesis exerts beneficial effects for the heart.
Exercise can induce physiological cardiac growth with cardiomyocyte hypertrophy and …

In recent years, the study of lymphangiogenesis and fibrotic diseases has made
considerable achievements, and accumulating evidence indicates that lymphangiogenesis …

The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

Obesity, insulin resistance, dyslipidemia, and hypertension are fundamental clinical
manifestations of the metabolic syndrome. Studies over the last few decades have …