Genomic DNA is wrapped around a core histone octamer and forms a nucleosome. In
higher eukaryotic cells, strings of nucleosomes are irregularly folded as chromatin domains …

Single-molecule tracking (SMT) has emerged as the dominant technology to investigate the
dynamics of chromatin-transcription factor (TF) interactions. How long a TF needs to bind to …

Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced
fluorescence microscopy, FPs can report on additional intracellular variables. One variable …

How chromatin dynamics relate to transcriptional activity remains poorly understood. Using
single-molecule tracking, coupled with machine learning, we show that histone H2B and …

Although our understanding of the involvement of heterochromatin architectural factors in
shaping nuclear organization is improving, there is still ongoing debate regarding the role of …

Genomic information must be faithfully transmitted into two daughter cells during mitosis. To
ensure the transmission process, interphase chromatin is further condensed into mitotic …

An array of motor proteins consumes chemical energy in setting up the architectures of
chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by …

Cell viability assessment is critical, yet existing assessments are not accurate enough. We
report a cell viability evaluation method based on the metabolic ability of a single cell …

For accurate mitotic cell division, replicated chromatin must be assembled into
chromosomes and faithfully segregated into daughter cells. While protein factors like …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …