The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-
9) represents the largest and most complex member. We focus here on the biochemical …

Kaposi's sarcoma had been recognized as unique human cancer for a century before it
manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of …

Purpose To determine the molecular basis of corneal avascularity during wound healing
and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis …

Kaposi sarcoma (KS) remains a challenge. Its classic or Mediterranean form tends to be
benign. In transplant recipients it may be less so. As part of the AIDS pandemic, of which it …

Abstract Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence
or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are a subfamily
of metzincins. Matrix metalloproteinases are responsible for much of the turnover of extra …

Purpose Matrix metalloproteinases (MMPs) are involved in tumor metastasis and are
overexpressed in Kaposi's sarcoma (KS) cells. In a phase I trial of the MMP inhibitor COL-3 …

HIV protease inhibitors are antiretroviral drugs that block the enzyme required for production
of infectious viral particles. Although these agents have been designed to selectively bind to …

Copolymers based on N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that have been broadly implemented in the delivery of …

Copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that have been broadly implemented in the delivery of …