Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Recent successes in developing small molecule degraders that act through the ubiquitin
system have spurred efforts to extend this technology to other mechanisms, including the …
system have spurred efforts to extend this technology to other mechanisms, including the …
Targeting LC3/GABARAP for degrader development and autophagy modulation
Recent successes in developing small-molecule degraders that act through the ubiquitin
system have spurred efforts to extend this technology to other mechanisms, including the …
system have spurred efforts to extend this technology to other mechanisms, including the …
High-Throughput Screening for LC3/GABARAP Binders Utilizing the Fluorescence Polarization Assay
The characterization of interactions between autophagy modifiers (Atg8-family proteins) and
their natural ligands (peptides and proteins) or small molecules is important for a detailed …
their natural ligands (peptides and proteins) or small molecules is important for a detailed …
[HTML][HTML] Machine learning approaches for the identification of ligands of the autophagy marker LC3
The LC3 proteins play a crucial role in autophagy by participating to the formation of the
autophagosome. Modulation of autophagy by molecular interference with LC3 proteins …
autophagosome. Modulation of autophagy by molecular interference with LC3 proteins …
[引用][C] High-throughput screening and hit validation with a fluorescence polarization assay
MP Schwalm, J Dopfer, S Knapp