Therapeutic cancer vaccines

M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy

L Cai, Y Li, J Tan, L Xu, Y Li - Journal of hematology & oncology, 2023 - Springer
In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become
a new pillar of cancer treatment following surgery, radiation, chemotherapy, and targeted …

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

LB Darragh, J Gadwa, TT Pham, B Van Court… - Nature …, 2022 - nature.com
In the setting of conventional radiation therapy, even when combined with immunotherapy,
head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is …

Resistance mechanisms of anti-PD1/PDL1 therapy in solid tumors

Q Lei, D Wang, K Sun, L Wang… - Frontiers in cell and …, 2020 - frontiersin.org
In cancer-immunity cycle, the immune checkpoint PD1 and its ligand PDL1 act as
accomplices to help tumors resist to immunity-induced apoptosis and promote tumor …

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

B Farhood, M Najafi… - Journal of cellular …, 2019 - Wiley Online Library
CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer.
During cancer progression, CTLs encounter dysfunction and exhaustion due to …

[HTML][HTML] FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets

R Saleh, E Elkord - Cancer letters, 2020 - Elsevier
T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Y Pan, W Tang, W Fan, J Zhang, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

LB Darragh, MM Knitz, J Hu, ET Clambey, J Backus… - Nature Cancer, 2022 - nature.com
Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

M Uribe-Herranz, S Rafail, S Beghi… - The Journal of …, 2020 - Am Soc Clin Investig
Alterations in gut microbiota impact the pathophysiology of several diseases, including
cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts …