Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures.
Approximately one-third of epilepsy patients will not achieve seizure freedom with medical …

Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it
all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating …

Background Epilepsy is one of the most common brain disorder and, despite the possible
use of several therapeutic options, many patients continue to have seizures for their entire …

Background Studies have shown conflicting results in the correlation between serotonin-1A
(5-HT1A) receptor binding levels in the brain and temporal lobe epilepsy (TLE). There is a …

The molecular basis for temporal lobe epileptogenesis remains poorly defined. Recent
evidence shows that serotonin 2C receptors (5-HT2CRs), NR2A and NR2B subunit …

Psychiatric comorbidities are prevalent in patients with epilepsy and greatly contribute to the
overall burden of disease. The availability of reliable biomarkers to diagnose epilepsy …

Experimental and clinical data suggest an impact of serotonergic signaling on seizure
susceptibility and epilepsy-associated psychiatric comorbidities. Previous µPET studies …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy. The exact etiology underlying SUDEP is unknown, but …

The last few years have seen accelerated progress in the field of neurology, encompassing
both an understanding of disease and novel forms of treatment. The translation of discovery …