The roles and mechanisms of actions of vitamin C in bone: new developments
P Aghajanian, S Hall… - Journal of Bone and …, 2015 - academic.oup.com
Vitamin C is an important antioxidant and cofactor that is involved in the regulation of
development, function, and maintenance of several cell types in the body. Deficiencies in …
development, function, and maintenance of several cell types in the body. Deficiencies in …
Graphene and graphene oxide induce ROS production in human HaCaT skin keratinocytes: the role of xanthine oxidase and NADH dehydrogenase
M Pelin, L Fusco, C Martín, S Sosa, J Frontiñán-Rubio… - Nanoscale, 2018 - pubs.rsc.org
The extraordinary physicochemical properties of graphene-based nanomaterials (GBNs)
make them promising tools in nanotechnology and biomedicine. Considering the skin …
make them promising tools in nanotechnology and biomedicine. Considering the skin …
Absorption of 1-dicysteinethioacetal–5-hydroxymethylfurfural in rats and its effect on oxidative stress and gut microbiota
Q Zhao, J Ou, C Huang, R Qiu, Y Wang… - Journal of agricultural …, 2018 - ACS Publications
The absorption of a 5-hydroxymethylfurfural (HMF)–cysteine adduct, 1-dicysteinethioacetal–
5-hydroxymethylfurfural (DCH), and its effect on antioxidant activity and gut microbiota were …
5-hydroxymethylfurfural (DCH), and its effect on antioxidant activity and gut microbiota were …
Thiopurine biotransformation and pharmacological effects: contribution of oxidative stress
M Pelin, S De Iudicibus, M Londero… - Current drug …, 2016 - ingentaconnect.com
Background: Thiopurine antimetabolites are important agents for the treatment of severe
diseases, such as acute lymphoblastic leukemia and inflammatory bowel disease. Their …
diseases, such as acute lymphoblastic leukemia and inflammatory bowel disease. Their …
Azaspiracids increase mitochondrial dehydrogenases activity in hepatocytes: Involvement of potassium and chloride ions
M Pelin, J Kilcoyne, C Florio, P Hess, A Tubaro, S Sosa - Marine drugs, 2019 - mdpi.com
Background: Azaspiracids (AZAs) are marine toxins that are produced by Azadinium and
Amphidoma dinoflagellates that can contaminate edible shellfish inducing a foodborne …
Amphidoma dinoflagellates that can contaminate edible shellfish inducing a foodborne …
[HTML][HTML] Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species
W Chaabane, ML Appell - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Thiopurines (azathioprine, 6-mercaptopurine and 6-thioguanine) are a class of
genotoxic drugs extensively used in the treatment of various illnesses including leukemia …
genotoxic drugs extensively used in the treatment of various illnesses including leukemia …
Photosensitized UVA-induced cross-linking between human DNA repair and replication proteins and DNA revealed by proteomic analysis
M Guven, K Barnouin, AP Snijders… - Journal of proteome …, 2016 - ACS Publications
Long wavelength ultraviolet radiation (UVA, 320–400 nm) interacts with chromophores
present in human cells to induce reactive oxygen species (ROS) that damage both DNA and …
present in human cells to induce reactive oxygen species (ROS) that damage both DNA and …
Thioguanine restoration through type I photosensitization-superoxide oxidation-glutathione reduction cycles
N Euceda, J Jahnke, A Espinal, MF Louis… - Physical Chemistry …, 2021 - pubs.rsc.org
UVA-induced deleterious effect of thiopurine prodrugs including azathioprine, 6-
mercaptopurine and 6-thioguanine (6-TG) increases the risk of cancer development due to …
mercaptopurine and 6-thioguanine (6-TG) increases the risk of cancer development due to …
Insights into the cellular pharmacokinetics and pharmacodynamics of thiopurine antimetabolites in a model of human intestinal cells
E Genova, M Lucafò, M Pelin, V Di Paolo… - Chemico-Biological …, 2021 - Elsevier
Thiopurines, immunomodulating drugs used in the management of different chronic
autoimmune conditions and as anti-leukemic agents, may exert in some cases …
autoimmune conditions and as anti-leukemic agents, may exert in some cases …
Heuristics in role of human glutathione S-transferase Mu 1 as nitric oxide carrier and its engineered variants for enhanced activity
RK Aravilli, V Kohila, SL Vikram - Current pharmaceutical …, 2021 - ingentaconnect.com
Background: Human glutathione S-transferases (hGSTs) are phase-II detoxification
enzymes that catalyze the conjugation of electrophilic compounds and glutathione …
enzymes that catalyze the conjugation of electrophilic compounds and glutathione …