In the last twenty years, significant progress in understanding the pathophysiology of age-
associated neurodegenerative diseases has been made. However, the prevention and …

Human HtrA1-4 proteins belong to the HtrA family of evolutionarily conserved serine
proteases and function as important modulators of many physiological processes, including …

Objective: To elucidate the molecular mechanism of mutant HTRA1-dependent cerebral
small vessel disease in heterozygous individuals. Methods: We recruited 113 unrelated …

Excessive aggregation of proteins has a major impact on cell fate and is a hallmark of
amyloid diseases in humans. To resolve insoluble deposits and to maintain protein …

Genetic polymorphisms in the region of the trimeric serine hydrolase high-temperature
requirement 1 (HTRA1) are associated with increased risk of age-related macular …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Aims Cerebral small vessel disease (SVD) is the leading cause of vascular dementia.
Although the most of cases are sporadic, familial monogenic causes have been identified in …

Despite comprehensive research efforts over the last decades, the pathomechanisms of age-
related macular degeneration (AMD) remain far from being understood. Large-scale …

The outer layer of the human placenta comprises syncytiotrophoblast, which forms through
fusion of cytotrophoblasts (syncytialization), and plays a critical role in maternal–fetal …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly population. Variants in the HTRA1-ARMS2 locus have been linked to increased …