The outer membrane protects Gram‐negative bacteria against a harsh environment. At the
same time, the embedded proteins fulfil a number of tasks that are crucial to the bacterial …

The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

Gram-negative bacteria possess an outer membrane layer which constrains uptake and
secretion of solutes and polypeptides. To overcome this barrier, bacteria have developed …

Integral β-barrel proteins (OMPs) are a major class of outer membrane proteins in Gram-
negative bacteria. In Escherichia coli, these proteins are synthesized in the cytoplasm …

Porins and specific channels both produce water‐filled pores that allow the transmembrane
diffusion of small solutes, but the latter contain specific ligandbinding sites within the …

Recent advances in the study of bacterial membranes have led to the identification of a
multicomponent YaeT complex in the outer membrane (OM) of Gram‐negative bacteria that …

Biologic membranes are not simply inert physical barriers, but complex and dynamic
environments that affect membrane protein structure and function. Residing within these …

Using a cross-linking approach, we have analyzed the function of Skp, a presumed
molecular chaperone of the periplasmic space of Escherichia coli, during the biogenesis of …

We have studied the refolding and membrane insertion of the outer membrane protein
OmpA of Escherichia coli. The protein was extracted from its native membrane by sonication …

Thioredoxin, a ubiquitous and evolutionarily conserved protein, modulates the structure and
activity of proteins involved in a spectrum of processes, such as gene expression, apoptosis …