Aging in COVID-19: Vulnerability, immunity and intervention
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
Paradoxical changes in innate immunity in aging: recent progress and new directions
RR Montgomery, AC Shaw - Journal of Leucocyte Biology, 2015 - academic.oup.com
Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …
The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination
Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …
Dimensionality reduction by UMAP reinforces sample heterogeneity analysis in bulk transcriptomic data
Transcriptomic analysis plays a key role in biomedical research. Linear dimensionality
reduction methods, especially principal-component analysis (PCA), are widely used in …
reduction methods, especially principal-component analysis (PCA), are widely used in …
Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases
In silico quantification of cell proportions from mixed-cell transcriptomics data
(deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize …
(deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize …
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
Abstract Systems vaccinology has defined molecular signatures and mechanisms of
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Adults older than 65 account for most of the deaths caused by respiratory influenza A virus
(IAV) infections, but the underlying mechanisms for this susceptibility are poorly understood …
(IAV) infections, but the underlying mechanisms for this susceptibility are poorly understood …
Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging
CFA de Bourcy, CJL Angel… - Proceedings of the …, 2017 - National Acad Sciences
The elderly have reduced humoral immunity, as manifested by increased susceptibility to
infections and impaired vaccine responses. To investigate the effects of aging on B-cell …
infections and impaired vaccine responses. To investigate the effects of aging on B-cell …
Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses
HIPC-CHI Signatures Project Team… - Science …, 2017 - science.org
Annual influenza vaccinations are currently recommended for all individuals 6 months and
older. Antibodies induced by vaccination are an important mechanism of protection against …
older. Antibodies induced by vaccination are an important mechanism of protection against …
Utilizing population variation, vaccination, and systems biology to study human immunology
JS Tsang - Trends in immunology, 2015 - cell.com
The move toward precision medicine has highlighted the importance of understanding
biological variability within and across individuals in the human population. In particular …
biological variability within and across individuals in the human population. In particular …