TAR DNA-binding protein 43 (TDP-43) is involved in key processes in RNA metabolism and
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders on a disease spectrum that are characterized by the …

Abstract “Membraneless organelles,” also referred to as biomolecular condensates, perform
a variety of cellular functions and their dysregulation is implicated in cancer and …

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …

Cellular organization is determined by a combination of membrane-bound and membrane-
less biomolecular assemblies that range from clusters of tens of molecules to micrometer …

Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective
elimination of dysfunctional mitochondria. To this date, parkin depletion has been …

The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐
prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis …

Several RNA binding proteins involved in membraneless organelles can form pathological
amyloids associated with neurodegenerative diseases, but the mechanisms of how this …

TDP-43 is a nucleic acid-binding protein that performs physiologically essential functions
and is known to undergo phase separation and aggregation during stress. Initial …

Mutations in TDP-43, a RNA-binding protein with multiple functions in RNA metabolism,
cause amyotrophic lateral sclerosis (ALS), but it is uncertain how defects in RNA biology …