The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …

Abstract Bromodomain‐containing protein 4 (BRD4), as the most studied member of the
bromodomain and extra‐terminal (BET) family, is a chromatin reader protein interpreting …

Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets
account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms …

Ineffective drug delivery and poor prognosis are two major challenges in the treatment of
pancreatic ductal adenocarcinoma (PDAC). While there is significant downregulation of …

Acute lymphoblastic leukemia (ALL) is an aggressive leukemia which can be derived from
either T-cell or B-cell precursors. With current treatments, the survival rate is high, but the …

Myc transcription factors are key regulators of many cellular processes, with Myc target
genes crucially implicated in the management of cell proliferation and stem pluripotency …

GATA‐3 regulates the differentiation, proliferation, survival, and function of peripheral T cells
and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA‐3 in …

High-risk lymphomas (HRLs) are associated with dismal outcomes and remain a therapeutic
challenge. Recurrent genetic and molecular alterations, including c-myc expression and …

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare and relatively
indolent B-cell lymphoma. Characteristically, the [lymphocyte-predominant (LP)] tumor cells …

Both Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV)
establish the persistent, life-long infection primarily at the latent status, and associate with …