Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Alteration in the expression of heparan sulfate (HS)-modifying enzymes has been frequently
observed in cancer. Consequently, dysregulation of the HS biosynthetic machinery results in …

Triple-negative breast cancer (TNBC) does not respond to many targeted drugs due to the
lack of three receptors (ie, estrogen receptor, progesterone receptor, and human epidermal …

Targeting heparan sulfate proteoglycans (HSPGs) and enzymes involved in heparan sulfate
(HS) chain editing is emerging as a new anticancer strategy. The involvement of HSPGs in …

Sulfonation is one of the most abundant cellular reactions modifying a wide range of
xenobiotics as well as endogenous molecules which regulate important biological …

Heparan sulfate (HS) 3-O-sulfotransferase isoform 4 (3-OST-4) is a specialized
carbohydrate sulfotransferase participating in the biosynthesis of heparan sulfate. Here, we …

The heparan sulfate proteoglycans (HSPGs) are glycoproteins that consist of a proteoglycan
“core” protein and covalently attached heparan sulfate (HS) chain. HSPGs are ubiquitously …

Emerging evidence suggests that the enzymes in the biosynthetic pathway for the synthesis
of heparan sulfate moieties of heparan sulfate proteoglycans (HSPGs) are epigenetically …

Breast cancer remains a leading cause of cancer-related mortality in women. In recent
years, regulation of genes involved in heparan sulphate (HS) biosynthesis have received …

Luminal breast cancer (BrCa) has a favorable prognosis compared with other tumor
subtypes. However, with time, tumors may evolve and lead to disease progression; thus …