Statins have been prescribed extensively for their cholesterol-lowering properties and
efficacy in cardiovascular disease. However, compelling evidence now exists that statins …

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most
common causes of death globally. It has been evident for more than 20 years that adaptive …

Motivated by the clinical observation that interruption of the mevalonate pathway stimulates
immune responses, we hypothesized that this pathway may function as a druggable target …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

Dendritic cells (DCs) are the most potent antigen-presenting cells. DCs were identified in
arteries in 1995 and, since then, further knowledge has been gained indicating the …

Atherosclerosis is an inflammatory disease regulated by several immune cells including
lymphocytes, macrophages and dendritic cells. Gut probiotic bacteria like Lactobacilli have …

Objective—Based on their role in T-cell homing into nonlymphoid tissue, we examined the
role of the homeostatic chemokines CCL19 and CCL21 and their common receptor CCR7 in …

Atherosclerosis has been considered a syndrome of dysregulated lipid storage until recent
evidence has emphasized the critical contribution of the immune system. Dendritic cells …

Background Multiple sclerosis (MS) is a chronic inflammatory disease that leads to
progressive disability. Statins [hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors] …