The interplay of the immune system with other aspects of physiology is continually being
revealed and in some cases studied in considerable mechanistic detail. A prime example is …

Our intestinal tract is colonized since birth by multiple microbial species that show a
characteristic succession in time. Notably the establishment of the microbiota in early life is …

Background Aberrant gene expression in the gut mucosa might contribute to the initiation
and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise …

In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which
provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been …

Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly
prevalent in low-and middle-income countries. It is thought to be a key contributing factor to …

Disruption of mucosal immunity plays a critical role in the pathogenesis of inflammatory
bowel disease, yet its mechanism remains not fully elucidated. Here, we found that …

Objective We recently demonstrated that hypoxia, a key feature of IBD, increases
enterochromaffin (EC) cell 5-HT secretion, which is also physiologically regulated by the …

Inflammatory bowel disease (IBD) encompasses several chronic inflammatory disorders
leading to the damage of the gastrointestinal tract. The 2 principal forms of these disorders …

Objectives To evaluate molecular profiles in the small bowel (SB) mucosa proximal to the
pouch in ulcerative colitis (UC) patients after pouch surgery. Design Patients were …

Purpose To investigate if texture analysis parameters of contrast-enhanced MRI differ
according to the presence of histological markers of hypoxia and angiogenesis in Crohn's …