Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

High‐level resistance to β‐lactam antibiotics in methicillin‐resistant Staphylococcus aureus
(MRSA) is due to expression of penicillin‐binding protein 2a (PBP2a), a transpeptidase that …

Antibiotic resistance is one of the greatest current threats to human health, and without
significant action we face the chilling prospect of a world without effective antibiotics …

The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical
resistance to the β-lactam antibiotics by methicillin-resistant Staphylococcus aureus (MRSA) …

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent bacterial
pathogens and continues to be a leading cause of morbidity and mortality worldwide. MRSA …

β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by
problems of resistance, and the development of new β-lactam antibiotics through side-chain …

Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers
called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d …

Despite the need for new antibiotics to treat drug-resistant bacteria, current clinical
combinations are largely restricted to β-lactam antibiotics paired with β-lactamase inhibitors …

Rising drug resistance is limiting treatment options for infections by methicillin-resistant
Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid …