Platelets are damage sentinels of the intravascular compartment, initiating and coordinating
the primary response to tissue injury. Severe trauma and hemorrhage induce profound …

Advancements in trauma care have been made because of improvements in blood storage,
prehospital and interhospital transport systems, and refinement of resuscitative and surgical …

Objective: Developing pragmatic data-driven algorithms for management of trauma induced
coagulopathy (TIC) during trauma hemorrhage for viscoelastic hemostatic assays (VHAs) …

Burn injury has severe impact on the physiologic homeostasis. Platelet counts show a
distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period …

Essentials• The response of thromboelastometry (ROTEM) parameters to therapy is
unknown.• We prospectively recruited hemorrhaging trauma patients in six level‐1 trauma …

Competitive endogenous RNA (ceRNA) networks play crucial roles in multiple biological
processes and development of diseases. They might serve as diagnostic and prognosis …

Coagulopathy is a known sequela of traumatic brain injury (TBI) and can lead to increased
morbidity and mortality. Platelet dysfunction has been identified as one of several etiologies …

Saving lives of wounded military warfighters often depends on the ability to resolve or
mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital …

Rotational thromboelastometry (ROTEM) can only detect high-degree hyperfibrinolysis (HF),
despite being frequently used in trauma patients. We investigated whether considering …

Methods: In the present study, we used a rat model of hemorrhagic shock and resuscitation
to more comprehensively assess glycocalyx disruption across a range of organs. Glycocalyx …