Lignans and neolignans are plant secondary metabolites derived from the oxidative
coupling of phenylpropanoids. Biological activity of these phenolic compounds ranges from …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …

Background High-grade glioma (HGG) is a fatal human cancer. Bortezomib, a proteasome
inhibitor, has been approved for the treatment of multiple myeloma but its use in glioma …

FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in
multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has …

Medulloblastoma, an embryonal tumor of the cerebellum/fourth ventricle, is one of the most
frequent malignant brain tumors in children. Although genetic variants are increasingly used …

Abstract Forkhead Box M1 (FOXM1) is known to regulate cell proliferation, apoptosis and
tumorigenesis. The lignan,(−)-(2R, 3R)-1, 4-O-diferuloylsecoisolariciresinol (DFS), from …

Background Natural medicines have a long history in the prevention and treatment of
various diseases in East Asian region, especially in China. Modern research has proved that …

Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer,
lacking common treatment targets such as estrogen (ER), progesterone (PR), and HER2 …

Epithelial ovarian cancer (EOC) is a highly lethal disease with poor prognosis especially in
advanced stage tumor. Emerging evidence has reported that aberrant upregulation of …