The emerging role of plant-derived exosomes-like nanoparticles in immune regulation and periodontitis treatment

Z Zhang, Y Yu, G Zhu, L Zeng, S Xu, H Cheng… - Frontiers in …, 2022 - frontiersin.org
Periodontitis is an infectious oral disease, which leads to the destruction of periodontal
tissues and tooth loss. Although the treatment of periodontitis has improved recently, the …

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Z Xu, Y Xu, K Zhang, Y Liu, Q Liang, A Thakur… - Journal of …, 2023 - Springer
Background The past few years have witnessed a significant increase in research related to
plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using …

Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum …

MC López de las Hazas, L del Pozo-Acebo… - European Journal of …, 2022 - Springer
Abstract Purpose Extracellular RNAs are unstable and rapidly degraded unless protected.
Bovine-milk extracellular vesicles (EVs) confer protection to dietary miRNAs, although it …

MicroRNAs from plants to animals, do they define a new messenger for communication?

Z Li, R Xu, N Li - Nutrition & metabolism, 2018 - Springer
MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides,
are potent regulators of gene expression existing in both plants and animals. Recent studies …

Digestion of plant dietary miRNAs starts in the mouth under the protection of coingested food components and plant-derived exosome-like nanoparticles

X Qin, X Wang, K Xu, Y Zhang, X Ren… - Journal of agricultural …, 2022 - ACS Publications
The regulatory functions of plant miRNAs on mammalian bodies are controversial, mainly
because stability of the miRNAs in the digestive tract, as the prerequisite for their cross …

Potential mechanisms linking food-derived microRNAs, gut microbiota and intestinal barrier functions in the context of nutrition and human health

E Díez-Sainz, S Lorente-Cebrián, P Aranaz… - Frontiers in …, 2021 - frontiersin.org
MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules from 18 to 24
nucleotides that are produced by prokaryote and eukaryote organisms, which play a crucial …

The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint

MY Momin, RR Gaddam, M Kravitz, A Gupta, A Vikram - Cells, 2021 - mdpi.com
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

Milk miRNAs encapsulated in exosomes are stable to human digestion and permeable to intestinal barrier in vitro

P Rani, M Vashisht, N Golla, S Shandilya… - Journal of Functional …, 2017 - Elsevier
Milk exosomal miRNAs are bioactive nucleic acids. However, their stability against the
digestive processes and bioavailability to the cellular functions is still controversial. In the …

[HTML][HTML] Edible plant-derived extracellular vesicles serve as promising therapeutic systems

C Yang, W Zhang, M Bai, Q Luo, Q Zheng, Y Xu, X Li… - Nano TransMed, 2023 - Elsevier
Extracellular vesicles (EVs), which are natural nanocarriers characterized by a phospholipid
bilayer structure, are released by living cells. They play a crucial role in the intercellular …