A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

Phosphonates, often used as isosteric replacements for phosphates, can provide important
interactions with an enzyme. Due to their high charge at physiological pH, however …

Phosphoantigen-sensitive Vγ9Vδ2 T cells are important responders to infections and
malignancy. However, the mechanisms by which phosphoantigens stimulate Vγ9Vδ2 T cells …

Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …

Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have
been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs …

The posttranslational modification of protein prenylation is a covalent lipid modification on
the C-terminus of substrate proteins that serves to enhance membrane affinity. Oncogenic …

Proteins modified post‐translationally by geranylgeranylation have been implicated in
numerous cellular processes related to human disease. In recent years, the study of protein …

Bisphosphonates such as risedronate and ibandronate are widely used to treat a variety of
bone resorption diseases, preventing protein prenylation and disrupting osteoclast …

Inhibitors of isoprenoid biosynthesis are widely used to treat human disease including
statins and nitrogenous bisphosphonates. Due to the importance of core human isoprenoid …

Studies of triazole bisphosphonates have resulted in identification of a potent inhibitor of
geranylgeranyl diphosphate synthase (IC50= 45 nM) with very good selectivity for this …