The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …

Ferroptosis has emerged as a crucial regulated cell death involved in a variety of
physiological processes or pathological diseases, such as tumor suppression. Though …

Cancer-associated mutations that stabilize NRF2, an oxidant defense transcription factor,
are predicted to promote tumor development. Here, utilizing 3D cancer spheroid models …

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper
(Piper longum Linn.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or …

Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been
identified as a G-actin binding protein involved in blood clotting, tissue regeneration …

Ferroptosis is an iron-dependent form of programmed cell death, which plays crucial roles in
tumorigenesis, ischemia–reperfusion injury and various human degenerative diseases …

The thioredoxin family consists of a small group of redox proteins present in all organisms
and composed of thioredoxins (TRXs), glutaredoxins (GLRXs) and peroxiredoxins (PRDXs) …

Ferroptosis has been described recently as an iron-dependent cell death driven by
peroxidation of membrane lipids. It is involved in the pathogenesis of a number of diverse …

Abstract Glutathione peroxidase 4 (GPX4) is a promising anticancer therapeutic target;
however, the application of GPX4 inhibitors (GPX4i) is limited owing to intrinsic or acquired …

Dysregulated iron homeostasis underlies diverse pathologies, from ischemia-reperfusion
injury to epithelial-mesenchymal transition and drug-tolerant" persister" cancer cell states …