Complications of proton pump inhibitor therapy

MF Vaezi, YX Yang, CW Howden - Gastroenterology, 2017 - Elsevier
Safety issues associated with proton pump inhibitors (PPIs) have recently attracted
widespread media and lay attention. Gastroenterologists are frequently asked about the …

Proton pump inhibitors: review of emerging concerns

AK Nehra, JA Alexander, CG Loftus, V Nehra - Mayo Clinic Proceedings, 2018 - Elsevier
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized
medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are …

Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence

ML Maes, DR Fixen… - Therapeutic advances in …, 2017 - journals.sagepub.com
Proton-pump inhibitors (PPIs) are a widely prescribed class of medications used to treat acid-
related disorders and use has significantly increased over the last few decades. PPIs are …

Proton-pump inhibitors and risk of fractures: an update meta-analysis

B Zhou, Y Huang, H Li, W Sun, J Liu - Osteoporosis international, 2016 - Springer
To identify the relationship between proton-pump inhibitors (PPIs) and the risk of fracture, we
conducted an update meta-analysis of observational studies. Results showed that PPI use …

Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials

JS Lee, HR Collard, KJ Anstrom… - The Lancet …, 2013 - thelancet.com
Background Abnormal acid gastro-oesophageal reflux is common in patients with idiopathic
pulmonary fibrosis (IPF) and is considered a risk factor for development of IPF. Retrospective …

Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients

M Krag, A Perner, J Wetterslev, MP Wise… - Intensive care …, 2015 - Springer
Purpose To describe the prevalence of, risk factors for, and prognostic importance of
gastrointestinal (GI) bleeding and use of acid suppressants in acutely ill adult intensive care …

Proton pump inhibitors and bone health: An update narrative review

E Lespessailles, H Toumi - International journal of molecular sciences, 2022 - mdpi.com
Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They
decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which …

Risk of dementia in elderly patients with the use of proton pump inhibitors

B Haenisch, K von Holt, B Wiese, J Prokein… - European archives of …, 2015 - Springer
Drugs that modify the risk of dementia in the elderly are of potential interest for dementia
prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production …

The global, regional, and national burden of gastro-oesophageal reflux disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global …

MA Dirac, S Safiri, D Tsoi, RA Adedoyin… - The Lancet …, 2020 - thelancet.com
Background Gastro-oesophageal reflux disease is a common chronic ailment that causes
uncomfortable symptoms and increases the risk of oesophageal adenocarcinoma. We …

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies

TN Poly, MM Islam, HC Yang, CC Wu, YCJ Li - Osteoporosis International, 2019 - Springer
We performed a meta-analysis of relevant studies to quantify the magnitude of the
association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs …