Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes
mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease
(DKD), and their targeting may be an effective means for prevention. Proximal tubular (PT) …

Abstract Type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease
(CKD), are recognized among the most disruptive public health issues of the current century …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Chronic kidney disease affects~ 37 million adults in the US, and it is often undiagnosed due
to a lack of apparent symptoms in early stages. Chronic kidney disease (CKD) interferes with …

There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR)
are separate and independent risk factors for cardiovascular and renal events among …

Podocyte detachment and reduced endothelial cell fenestration and relationships between
these features and the classic structural changes of diabetic nephropathy have not been …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

The presence of albuminuria or proteinuria constitutes a sign of kidney damage and,
together with the estimation of glomerular filtration rate, is based on the evaluation of chronic …