In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …

Two decades ago, the pharmaceutical industry—long dominated by small-molecule drugs—
was revolutionized by the the advent of biologics. Today, biomedicine sits on the cusp of a …

Background CTX0E03 is an immortalised human neural stem-cell line from which a drug
product (CTX-DP) was developed for allogeneic therapy. Dose-dependent improvement in …

The human brain undergoes rapid development at mid-gestation from a pool of neural stem
and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes …

Alzheimer's disease (AD) is the most prevalent age‐related neurodegenerative disorder,
affecting over 35 million people worldwide. Pathologically, AD is characterized by the …

Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …

Pelizaeus-Merzbacher disease (PMD) is a rare leukodystrophy caused by mutation of the
proteolipid protein 1 gene. Defective oligodendrocytes in PMD fail to myelinate axons …

Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is
associated with significant and irreversible long-term side effects, including cognitive decline …

Injury to the preterm brain has a particular predilection for cerebral white matter. White
matter injury (WMI) is the most common cause of brain injury in preterm infants and a major …

Stem cell-based therapies hold considerable promise for many currently devastating
neurological disorders. Substantial progress has been made in the derivation of disease …