From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Drug discovery has traditionally focused on using libraries of small molecules to identify
therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic …

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein–
protein interactions. In contrast to the heavily automated high-throughput screening systems …

Highlights•SICLOPPS allows the rapid generation of cyclic peptide libraries in cells.•A
variety of cyclic peptide ring sizes may be generated with SICLOPPS.•SICLOPPS libraries …

To date, small molecules and macromolecules, including antibodies, have been the most
pursued substances in drug screening and development efforts. Despite numerous …

As antibiotic resistance increases worldwide, there is an increasing pressure to develop
novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics …

Phage display has demonstrated the utility of cyclic peptides as general protein ligands but
cannot access proteins inside eukaryotic cells. Expanding a new chemical genetics tool, we …

We report a bacterial system for the evolution of cyclic peptides that makes use of an
expanded set of amino acid building blocks. Orthogonal aminoacyl-tRNA …

Mycobacterium tuberculosis is a pathogen of major global importance. Validated drug
targets are required in order to develop novel therapeutics for drug-resistant strains and to …