The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the
phagocytic clearance of cellular debris has been considered an integral component of …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …

Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …

In the human body, billions of cells die by apoptosis every day. The subsequent clearance of
apoptotic cells by phagocytosis is normally efficient enough to prevent secondary necrosis …

Following its release into the extracellular space in response to metabolic disturbances, the
endogenous nucleoside adenosine exerts a range of immunomodulatory effects and cells of …