Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate
balance and producing hormones. Its development during childhood determines height and …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Mice are widely used in studies of skeletal biology, and assessment of their bones by
mechanical testing is a critical step when evaluating the functional effects of an experimental …

Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus
increasing blood volume and pressure. Excessive production of aldosterone results in high …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

Mechanical loading is the primary functional determinant of bone mass and architecture,
and osteocytes play a key role in translating mechanical signals into (re) modelling …

In the synovial joint, mechanical force creates an important signal that influences
chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on …

Mechanotransduction is pivotal in the maintenance of homeostasis in different tissues and
involves multiple cell signaling pathways. In bone, mechanical stimuli regulate the balance …

In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …

Mechanical loading is an anabolic stimulus that increases bone mass, and thus a promising
method to counteract osteoporosis-related bone loss. The mechanism of this anabolism …