Cryopreservation as a key element in the successful delivery of cell-based therapies—a review

J Meneghel, P Kilbride, GJ Morris - Frontiers in medicine, 2020 - frontiersin.org
Cryopreservation is a key enabling technology in regenerative medicine that provides stable
and secure extended cell storage for primary tissue isolates and constructs and prepared …

The anatomy of single cell mass cytometry data

LR Olsen, MD Leipold, CB Pedersen… - Cytometry Part …, 2019 - Wiley Online Library
Mass cytometry enables the measurement of up to 50 features on single cell. This has
catalyzed a shift toward multidimensional data analysis methods, rather than the manual …

Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity

G Noël, ML Fontsa, S Garaud… - The Journal of …, 2021 - Am Soc Clin Investig
We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …

[HTML][HTML] Tumor-infiltrating B cells signal functional humoral immune responses in breast cancer

S Garaud, L Buisseret, C Solinas, C Gu-Trantien… - JCI insight, 2019 - ncbi.nlm.nih.gov
Tumor-infiltrating B cells (TIL-B) in breast cancer (BC) have previously been associated with
improved clinical outcomes; however, their roles in tumor immunity are not currently well …

[HTML][HTML] CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

C Gu-Trantien, E Migliori, L Buisseret, A de Wind… - JCI insight, 2017 - ncbi.nlm.nih.gov
T follicular helper cells (T FH cells) are important regulators of antigen-specific B cell
responses. The B cell chemoattractant CXCL13 has recently been linked with T FH cell …

Tumor-infiltrating lymphocyte composition, organization and PD-1/PD-L1 expression are linked in breast cancer

L Buisseret, S Garaud, A de Wind… - …, 2017 - Taylor & Francis
The clinical relevance of tumor-infiltrating lymphocytes (TIL) in breast cancer (BC) has been
clearly established by their demonstrated correlation with long-term positive outcomes …

DNA methylation–based immune response signature improves patient diagnosis in multiple cancers

J Jeschke, M Bizet, C Desmedt… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. The tumor immune response is increasingly associated with better clinical
outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating …

An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression

L Wang, G Li, L Cao, Y Dong, Y Wang, S Wang, Y Li… - Science …, 2021 - science.org
Exploring facile and effective therapeutic modalities for synergistically controlling primary
tumor and metastasis remains a pressing clinical need. Sonodynamic therapy (SDT) offers …

Immune checkpoint molecules on tumor-infiltrating lymphocytes and their association with tertiary lymphoid structures in human breast cancer

C Solinas, S Garaud, P De Silva, A Boisson… - Frontiers in …, 2017 - frontiersin.org
There is an exponentially growing interest in targeting immune checkpoint molecules in
breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs …

Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer

S Garaud, P Zayakin, L Buisseret, U Rulle… - Frontiers in …, 2018 - frontiersin.org
An important role for tumor infiltrating B lymphocytes (TIL-B) in the immune response to
cancer is emerging; however, very little is known about the antigen specificity of antibodies …