Centrosomes are a functionally conserved feature of eukaryotic cells that play an important
role in cell division. The conserved γ-tubulin complex organizes spindle and astral …

Cytokinesis is essential for the survival of all organisms. It requires concerted functions of
cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the …

Governance of protein phosphorylation by kinases and phosphatases constitutes an
essential regulatory network in eukaryotic cells. Network dysregulation leads to severe …

In many eukaryotic organisms cytokinesis is driven by a contractile actomyosin ring (CAR)
that guides membrane invagination. What triggers CAR constriction at a precise time of the …

The evolution of multicellularity paved the way for the origin of complex life on Earth, but little
is known about the mechanistic basis of early multicellular evolution. Here, we examine the …

The septin collar of budding yeast is an ordered array of septin filaments that serves a
scaffolding function for the cytokinetic machinery at the bud neck and compartmentalizes the …

Mannoproteins are non-filamentous glycoproteins localized to the outermost layer of the
yeast cell wall. The physiological roles of these structural components have not been …

Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae,
variations in external osmolarity trigger the activation of the stress-activated protein kinase …

Abstract Background Protein phosphatase 2A (PP2A) is a family of conserved
serine/threonine phosphatases involved in several essential aspects of cell growth and …

Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is
the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells …