Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task
E Pick - Small GTPases, 2014 - Taylor & Francis
The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
C Onesto, A Shutes, V Picard, F Schweighoffer… - Methods in …, 2008 - Elsevier
There is now considerable experimental evidence that aberrant activation of Rho family
small GTPases promotes uncontrolled proliferation, invasion, and metastatic properties of …
small GTPases promotes uncontrolled proliferation, invasion, and metastatic properties of …
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
A Shutes, C Onesto, V Picard, B Leblond… - Journal of Biological …, 2007 - ASBMB
There is now considerable experimental evidence that aberrant activation of Rho family
small GTPases promotes the uncontrolled proliferation, invasion, and metastatic properties …
small GTPases promotes the uncontrolled proliferation, invasion, and metastatic properties …
Structure and function of Rho-type molecular switches in plants
A Berken, A Wittinghofer - Plant Physiology and Biochemistry, 2008 - Elsevier
Molecular switches of the Rho family, in concert with their associated regulators and
effectors are well known as important control elements of vital signaling pathways in …
effectors are well known as important control elements of vital signaling pathways in …
The structural basis for Cdc42-induced dimerization of IQGAPs
Summary In signaling, Rho-family GTPases bind effector proteins and alter their behavior.
Here we present the crystal structure of Cdc42· GTP bound to the GTPase-activating protein …
Here we present the crystal structure of Cdc42· GTP bound to the GTPase-activating protein …
Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling
PL Joyce, AD Cox - Cancer research, 2003 - AACR
Abstract Rac1, a Rho family GTPase, is a mediator of diverse cellular functions including
membrane ruffling, cell cycle progression, and transformation. Rac3, a close relative of …
membrane ruffling, cell cycle progression, and transformation. Rac3, a close relative of …
Structure of an inactive conformation of GTP-bound RhoA GTPase
Y Lin, S Lu, J Zhang, Y Zheng - Structure, 2021 - cell.com
By using 31 P NMR, we present evidence that the Rho family GTPase RhoA, similar to Ras
GTPases, exists in an equilibrium of conformations when bound to GTP. High-resolution …
GTPases, exists in an equilibrium of conformations when bound to GTP. High-resolution …
Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1
The Rho guanosine triphosphatases (GTPases) control cell shape and motility and are
frequently overexpressed during malignant growth. These proteins act as molecular …
frequently overexpressed during malignant growth. These proteins act as molecular …
[PDF][PDF] Cytoskeleton changes of airway smooth muscle cells in juvenile rats with airway remodeling in asthma and the RhoA/ROCK signaling pathway mechanism
B Wei, YX Shang, M Li, J Jiang, H Zhang - Genet Mol Res, 2014 - funpecrp.com.br
This article aimed to investigate changes in the cytoskeleton of airway smooth muscle cells
(ASMCs) in juvenile rats with airway remodeling in asthma. We further investigated the …
(ASMCs) in juvenile rats with airway remodeling in asthma. We further investigated the …
Allostery and dynamics in small G proteins
The Ras family of small guanine nucleotide-binding proteins behave as molecular switches:
they are switched off and inactive when bound to GDP but can be activated by GTP binding …
they are switched off and inactive when bound to GDP but can be activated by GTP binding …