For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-
invasively regulated is highly desirable to avoid further complications and to promote …

With increasing obesity and an ageing population, health complications are also on the rise,
such as the need to replace a joint with an artificial one. In both humans and animals, the …

Perinatal tissues, such as placenta and umbilical cord contain a variety of somatic stem cell
types, spanning from the largely used hematopoietic stem and progenitor cells to the most …

Abstract Three-dimensional (3D) scaffolds as artificial ECMs have been extensively studied
to mimic the critical features of natural ECMs. To develop more clinically relevant 3D …

Treatments of osteolytic lesions due to malignant metastasis remain one of the major clinical
challenges. The residual tumor cells after surgical resections and an acidic tumor …

Scaffolds can be defined as 3D architectures with specific features (surface properties,
porosity, rigidity, biodegradability, etc.) that help cells to attach, proliferate, and to …

A multifunctional material system that kills bacteria and drives bone healing is urgently
sought to improve bone prosthesis. Herein, the osteoinductive coating made of calcium …

In craniofacial bone defects, the promotion of bone volume augmentation remains a
challenge. Finding strategies for bone regeneration such as combining resorbable minerals …

While stem cell/biomaterial studies provide solid evidences that biomaterial intrinsic cues
deeply affect cell fate, current strategies tend to neglect their effects on mesenchymal stem …

Bone repair devices with proper mechanical strength and high biocompatibilities are highly
appealing in clinical treatment. The currently widely used Poly (ether ketone)(PEEK) …