This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Background Alcohol use disorder (AUD) and alcoholrelated impairments belong to the
most widespread psychiatric disorders leading to specific psychophysical, affective and …

Background: Recent clinical trials and casereports indicate that baclofen, a GABAB agonist,
may have efficacy for alcohol dependence. Baclofen has been shown to enhance …

Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and
morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B (GABA-B) receptor …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Sardinian alcoholpreferring (sP) andnonpreferring (sNP) rats are one of the pairs of rat
lines selectively bred for high and low alcohol preference and consumption, respectively …

The purpose of this review paper is to present evidence that rat animal models of alcoholism
provide an ideal platform for developing and screening medications that target alcohol …

Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We
recently used alcohol self-administration that is resistant to footshock punishment as a …

The present paper summarizes the preclinical and clinical studies conducted to define the
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …