Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Branched actin assembly is critical for a variety of cellular processes that underlie cell
motility and invasion, including cellular protrusion formation and membrane trafficking …

Invadopodia are branched actin-rich structures associated with extracellular matrix (ECM)
degradation that collectively form the invasive machinery of aggressive cancer cells …

Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed
in cancer. Animal studies suggest that cortactin overexpression increases tumor …

Invasion of tissues by malignant tumours is facilitated by tumour cell migration and
degradation of extracellular matrix (ECM) barriers. Several invasive neoplasms, including …

Invadopodia are actin-dependent organelles that function in the invasion and remodeling of
the extracellular matrix (ECM) by tumor cells. Cortactin, a regulator of the Arp2/3 complex, is …

Metastatic cancer cells have the ability to both degrade and migrate through the extracellular
matrix (ECM). Invasiveness can be correlated with the presence of dynamic actin-rich …

Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a
central element connecting signaling pathways with cytoskeleton restructuring. It is involved …

Osteoclasts are multinucleated cells that are responsible for resorption of bone, and
increased activity of these cells is associated with several common bone diseases, including …

Basement membrane transmigration during embryonal development, tissue homeostasis
and tumor invasion relies on invadosomes, a collective term for invadopodia and …