HIV-1 assembly, budding, and maturation
WI Sundquist, HG Kräusslich - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …
HIV-1 maturation: lessons learned from inhibitors
AB Kleinpeter, EO Freed - Viruses, 2020 - mdpi.com
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …
effective therapies has accompanied a massive increase in our understanding of the …
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
HIV capsid is a tractable target for small molecule therapeutic intervention
WS Blair, C Pickford, SL Irving, DG Brown… - PLoS …, 2010 - journals.plos.org
Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant
strains continue to emerge, underscoring the need for additional novel mechanism inhibitors …
strains continue to emerge, underscoring the need for additional novel mechanism inhibitors …
A stable immature lattice packages IP6 for HIV capsid maturation
HIV virion assembly begins with the construction of an immature lattice consisting of Gag
hexamers. Upon virion release, protease-mediated Gag cleavage leads to a maturation …
hexamers. Upon virion release, protease-mediated Gag cleavage leads to a maturation …
Multiple roles of HIV-1 capsid during the virus replication cycle
M Novikova, Y Zhang, EO Freed, K Peng - Virologica Sinica, 2019 - Springer
Human immunodeficiency virus-1 capsid (HIV-1 CA) is involved in different stages of the
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …
Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding
The mature HIV-1 capsid protects the viral genome and interacts with host proteins to travel
from the cell periphery into the nucleus. To achieve this, the capsid protein, CA, constructs …
from the cell periphery into the nucleus. To achieve this, the capsid protein, CA, constructs …
Human Immunodeficiency Virus Gag and protease: partners in resistance
A Fun, AMJ Wensing, J Verheyen, M Nijhuis - Retrovirology, 2012 - Springer
Abstract Human Immunodeficiency Virus (HIV) maturation plays an essential role in the viral
life cycle by enabling the generation of mature infectious virus particles through proteolytic …
life cycle by enabling the generation of mature infectious virus particles through proteolytic …
Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes
L Lamorte, S Titolo, CT Lemke… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The identification of novel antiretroviral agents is required to provide alternative treatment
options for HIV-1-infected patients. The screening of a phenotypic cell-based viral replication …
options for HIV-1-infected patients. The screening of a phenotypic cell-based viral replication …
HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules
A Saito, M Yamashita - Retrovirology, 2021 - Springer
The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …
multiple post-entry processes during viral replication. Many host factors can directly bind to …