Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action
and involve genomic processes. Because of the rapidity of some of the GC effects, however …

Flavonoids are polyphenolic compounds produced by plants and delivered to the human
body through food. Although the epidemiological analyses of large human populations did …

Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung
function. Stretching of alveoli during lung inflation is the main trigger for surfactant secretion …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Hydrocephalic hyh mutant mice undergo a programmed loss of the neuroepithelium/
ependyma followed by a reaction of periventricular astrocytes, which form a new cell layer …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …

Since ancient times, anticholinergics have been used as a bronchodilator therapy for
obstructive lung diseases. Targets of these drugs are G-protein-coupled muscarinic M1, M2 …

DNA methylation is essential for embryonic and neuronal differentiation, but the function of
most genomic DNA methylation marks is poorly understood. Generally the human genome …