Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Several controlled clinical studies have evaluated the potential of the infection biomarker
procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections …

Background Early recognition is a key factor to achieve improved outcomes for septic
patients. Combinations of biomarkers, as opposed to single ones, may improve timely …

The diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most
studies have used ambiguous outcome measures such as sepsis instead of infection. We …

Mid-regional pro-adrenomedullin (MR-proADM) has a good biomarker profile: its half-life is
several hours, and its plasma concentrations can be determined in clinical practice, it is …

Background Bacteremia is indicative of severe bacterial infection with significant mortality. Its
early diagnosis is extremely important for implementation of antimicrobial therapy but a …

OBJECTIVES: Serum procalcitonin is often ordered at admission for patients with suspected
sepsis and bloodstream infections (BSIs), although its performance characteristics in this …

Background The early diagnosis of sepsis is hampered by the lack of reliable laboratory
measures. There is growing evidence that presepsin and Mid-regional pro-adrenomedullin …

Previous studies have suggested that procalcitonin is a reliable marker for predicting
bacteremia. However, these studies have had relatively small sample sizes or focused on a …

Early identification and diagnosis of sepsis and septic shock is vitally important; despite
appropriate management, mortality and morbidity rates remain high. For this reason, many …