The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Long non-coding RNAs (lncRNAs) impact cell function via numerous mechanisms. In the
nucleus, interactions between lncRNAs and DNA and the consequent formation of non …

RNA can directly bind to purine-rich DNA via Hoogsteen base pairing, forming a DNA: RNA
triple helical structure that anchors the RNA to specific sequences and allows guiding of …

Attenuation of pre-rRNA synthesis in response to elevated temperature is accompanied by
increased levels of PAPAS (“promoter and pre-rRNA antisense”), a long noncoding RNA …

Abstract DNA: DNA: RNA triplexes that are formed through Hoogsteen base-pairing of the
RNA in the major groove of the DNA duplex have been observed in vitro, but the extent to …

Central nervous system (CNS) disorders, such as ischemic stroke, neurodegenerative
diseases, multiple sclerosis, traumatic brain injury, and corresponding neuropathological …

The genomes of mammalian species are pervasively transcribed producing as many
noncoding as protein-coding RNAs. There is a growing body of evidence supporting their …

The existence of dynamic cellular phenotypes in changing environmental conditions is of
major interest for cell biologists who aim to understand the mechanism and sequence of …

Mammalian genomes are extensively transcribed, producing a large number of coding and
non-coding transcripts. A large fraction of the nuclear RNAs is physically associated with …

Colorectal cancers have become the second leading cause of cancer-related deaths. In
particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer …